Isolated blood vessel models for studying trauma

Abnormalities of cerebrovascular circulation are one of the salient consequences of traumatic brain injury. Severity of cerebral blood flow disregulation is associated with the negative clinical outcome. Regulation of cerebral blood flow is complex and differs from regulation of blood flow in other vascular beds. Basic vascular tone formed by interaction of vascular smooth muscle cells and endothelium provides background for other regulatory mechanisms. Understanding of traumatic brain injury-induced abnormalities of basic vascular tone formation and its adjustment using isolated brain vessel model is important for unveiling the pathophysiological mechanisms of brain trauma and development of new therapeutic approaches.