Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease

Joshua P. Fessel, Christine Hulette, Suzanne Powell, L. Jackson Roberts, Jing Zhang

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

F2-isoprostanes (F2-IsoPs) are well-established sensitive and specific markers of oxidative stress in vivo. Isofurans (IsoFs) are also products of lipid peroxidation, but in contrast to F2-IsoPs, their formation is favored when oxygen tension is increased in vitro or in vivo. Mitochondrial dysfunction in Parkinson's disease (PD) may not only lead to oxidative damage to brain tissue but also potentially result in increased intracellular oxygen tension, thereby influencing relative concentrations of F2-isoPs and IsoFs. In this study, we attempted to compare the levels of F2-IsoPs and IsoFs esterified in phospholipids in the substantia nigra (SN) from patients with PD to those of age-matched controls as well as patients with other neurodegenerative diseases, including dementia with Lewy body disease (DLB), multiple system atrophy (MSA), and Alzheimer's disease (AD). The results demonstrated that IsoFs but not F2-IsoPs in the SN of patients with PD and DLB were significantly higher than those of controls. Levels of IsoFs and F2-IsoPs in the SN of patients with MSA and AD were indistinguishable from those of age-matched controls. This preferential increase in IsoFs in the SN of patients with PD or DLB not only indicates a unique mode of oxidant injury in these two diseases but also suggests different underlying mechanisms of dopaminergic neurodegeneration in PD and DLB from those of MSA.

Original languageEnglish (US)
Pages (from-to)645-650
Number of pages6
JournalJournal of Neurochemistry
Volume85
Issue number3
DOIs
StatePublished - May 2003

Keywords

  • Free radicals
  • Isofurans
  • Isoprostanes
  • Lipid peroxidation
  • Oxidative stress
  • Parkinson's disease

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Isofurans, but not F<sub>2</sub>-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease'. Together they form a unique fingerprint.

Cite this