Island grafts: A model for studying skin regeneration in isolation from other processes

Dennis P. Orgill, Charles E. Butler

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


This chapter introduces the concept of an island graft, in which large full-thickness skin wounds are created with a small treatment area in the center. The island graft is a simple method for demonstrating the effect of epithelial derivatives on wound regeneration without using sophisticated biologic or genetic markers. In the absence of disease, mammalian wounds of the dermis close by scarring and contraction. The island graft permits observation of the test material within the wound without interference from the periphery for several days until wound contraction and epithelialization of the surrounding skin encroach upon the study area.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine I
Subtitle of host publicationTheories, Models and Methods
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages12
ISBN (Print)3540228713, 9783540228714
StatePublished - Jan 28 2005

Publication series

NameAdvances in Biochemical Engineering/Biotechnology
ISSN (Print)0724-6145


  • Island graft
  • Regeneration
  • Wound model

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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