Is there a neural stem cell in the mammalian forebrain?

Samuel Weiss, Brent A. Reynolds, Angelo L. Vescovi, Cindi Morshead, Constance G. Craig, Derek Van Der Kooy

Research output: Contribution to journalReview articlepeer-review

489 Scopus citations


Neural precursor cells have been of interest historically as the building blocks of the embryonic CNS and, most recently, as substrates for restorative neurological approaches. The majority of previous in vitro studies of the regulation of neural-cell proliferation by polypeptide growth factors, and in vivo studies of neural lineage, argue for the presence of precursors with limited proliferative or lineage potential in the mammalian CNS. This is in contrast to renewable tissues, such as the blood or immune system, skin epithelium and epithelium of the small intestinal crypts, which contain specialized, self-renewing cells known as stem cells. However, recent in vitro and in vivo studies from our and other laboratories lead us to conclude that neural stem cells, with self-renewal and multilineage potential, are present in the embryonic through to adult mammalian forebrain.

Original languageEnglish (US)
Pages (from-to)387-393
Number of pages7
JournalTrends in Neurosciences
Issue number9
StatePublished - Sep 1996

ASJC Scopus subject areas

  • Neuroscience(all)


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