Is reliance on an inaccurate genome sequence sabotaging your experiments?

Rodrigo P. Baptista, Jessica C. Kissinger

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Advances in genomics have made whole genome studies increasingly feasible across the life sciences. However, new technologies and algorithmic advances do not guarantee flawless genomic sequences or annotation. Bias, errors, and artifacts can enter at any stage of the process from library preparation to annotation. When planning an experiment that utilizes a genome sequence as the basis for the design, there are a few basic checks that, if performed, may better inform the experimental design and ideally help avoid a failed experiment or inconclusive result.

Original languageEnglish (US)
Article numbere1007901
JournalPLoS pathogens
Issue number9
StatePublished - 2019

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology


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