O PET/CT interim com fluoreto- 18 F é capaz de predizer desfechos após a terapia com rádio-223?

Translated title of the contribution: Is interim 18 f-fluoride PET/CT a predictor of outcomes after radium-223 therapy?

Elba Etchebehere, Ana Emília Brito, Kalevi Kairemo, Eric Rohren, John Araujo, Homer Macapinlac

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Objective: To determine whether an interim 18 F-fluoride positron-emission tomography/computed tomography (PET/CT) study performed after the third cycle of radium-223 dichloride ( 223 RaCl 2 ) therapy is able to identify patients that will not respond to treatment. Materials and Methods: We retrospectively reviewed 34 histologically confirmed cases of hormone-refractory prostate cancer with bone metastasis in patients submitted to 223 RaCl 2 therapy. All of the patients underwent baseline and interim 18 F-fluoride PET/CT studies. The interim study was performed immediately prior to the fourth cycle of 223 RaCl 2 . The skeletal tumor burden—expressed as the total lesion fluoride uptake above a maximum standardized uptake value of 10 (TLF 10 )—was calculated for the baseline and the interim studies. The percent change in TLF 10 between the baseline and interim studies (%TFL 10 ) was calculated as follows: %TFL 10 = interim TLF 10 − baseline TLF 10 / baseline TLF 10 . End points were overall survival, progression-free survival, and skeletal-related events. Results: The mean age of the patients was 72.4 ± 10.2 years (range, 43.3–88.8 years). The %TLF 10 was not able to predict overall survival (p = 0.6320; hazard ratio [HR] = 0.753; 95% confidence interval [CI]: 0.236–2.401), progression-free survival (p = 0.5908; HR = 1.248; 95% CI: 0.557–2.797) nor time to a bone event (p = 0.5114; HR = 1.588; 95% CI: 0.399–6.312). Conclusion: The skeletal tumor burden on an interim 18 F-fluoride PET/CT, performed after three cycles of 223 RaCl 2 , is not able to predict overall survival, progression-free survival, or time to bone event, and should not be performed to monitor response at this time.

Translated title of the contribution Is interim 18 f-fluoride PET/CT a predictor of outcomes after radium-223 therapy?
Original languagePortuguese
Pages (from-to)33-40
Number of pages8
JournalRadiologia Brasileira
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • Bone neoplasms/diagnostic imaging
  • Positron-emission tomography/methods
  • Prostatic neoplasms
  • Radium-223
  • Sodium fluoride
  • Tomography,X-ray computed/methods
  • Tumor burden

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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