Is high-grade adenomatous hyperplasia an early bronchioloalveolar adenocarcinoma?

R. Ullmann, M. Bongiovanni, I. Halbwedl, A. E. Fraire, Philip T. Cagle, M. Mori, M. Papotti, Helmut H. Popper

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Atypical adenomatous hyperplasia (AAH) is a probable forerunner of bronchioloalveolar carcinoma (BAC) and pulmonary adenocarcinoma (AC) of mixed type. The present study analysed four low-grade AAHs, 13 high-grade AAHs, two BACs, nine mixed ACs, and one squamous cell carcinoma derived from 13 patients using comparative genomic hybridization. The average number of chromosomal aberrations was 1.2 in low-grade AAH, 9.6 in high-grade AAH, and 12.5 in AC. A high degree of overlap of genetic changes was found in high-grade AAH, BAC, and AC within individual patients. The high number of aberrations and the degree of shared aberrations found in high-grade AAH and AC raises questions about the separation of these two entities. In addition, in view of the monoclonal origin of multiple foci within the same patient, AAH may not be a precursor of AC in some cases, but rather may represent intraepithelial spread.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
JournalJournal of Pathology
Volume201
Issue number3
DOIs
StatePublished - Nov 1 2003

Keywords

  • AAH
  • Adenocarcinoma
  • Atypical adenomatous hyperplasia
  • Bronchioalveolar carcinoma
  • CGH

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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