Irreversible Renal Failure Following Vesicoureteral Reflux

Harry O. Senekjian, Bobby J. Stinebaugh, Wadi N. Suki, Carlos A. Mattioli

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Antireflux surgery was performed in five patients with vesicoureteral reflux at a time when renal insufficiency was present. Notable proteinuria was present in four of the patients, and a kidney biopsy specimen showed glomerular lesions in one. Despite the eradication of reflux and of infection, all five patients continued to have progressive renal insufficiency culminating in renal failure. Vesicoureteral reflux nephropathy may include a glomerulopathy leading to progressive glomerular sclerosis. Antireflux surgery would not alter this ongoing process and therefore would not halt progressive renal failure.

Original languageEnglish (US)
Pages (from-to)160-162
Number of pages3
JournalJournal of the American Medical Association
Issue number2
StatePublished - Jan 12 1979

ASJC Scopus subject areas

  • Medicine(all)


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