Iron chelation and neuroprotection in neurodegenerative diseases.

Xuping Li, Joseph Jankovic, Weidong Le

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

Iron is an essential element for multiple functions of the brain. Maintenance of iron homeostasis involves regulation of iron influx, iron efflux and iron storage. Mismanagement of brain iron has been implicated in neuronal injury and death in several neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (PD) and Amyotrophic lateral sclerosis (ALS). Multiple iron chelators have been shown neuroprotective and neurorestorative in these diseases, suggesting that iron chelation might be a promising therapeutics. In this paper, we briefly review the new findings of biological function of several molecules that regulate iron homeostasis in the brain, the possible role of iron mismanagement in the pathogenesis of PD, AD and ALS, and then discuss the putative mechanisms for current available iron chelators as potential therapeutics for neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalJournal of neural transmission (Vienna, Austria : 1996)
Volume118
Issue number3
DOIs
StatePublished - Mar 1 2011

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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