Iodine quantification and detectability thresholds among major dual-energy CT platforms

Ross Edward Taylor, Pamela Mager, Nam C. Yu, David P. Katz, Jett R. Brady, Nakul Gupta

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objectives: To estimate the minimum detectable iodine concentration on multiple dual-energy CT (DECT) platforms. Methods and materials: A phantom containing iodine concentrations ranging from 0 to 10 mg ml-1 was scanned with five dual-energy platforms (two rapid kilo volt switching (r-kVs), one dual source (DS), one sequential acquisition and one split-filter). Serial dilutions of 300 mg ml-1 iodinated contrast material were used to generate concentrations below 2 mg ml-1. Iodine density and virtual monoenergetic images were reviewed by three radiologists to determine the minimum visually detectable iodine concentration. Contrast-to-noise ratios (CNRs) were calculated. Results: 1 mg mL-1 (0.8 mg mL-1 corrected) was the minimum visually detectable concentration among the platforms and could be seen by all readers on the third-generation r-kVs and DS platforms. Conclusions: At low concentrations, CNR for monoenergetic images was highest on the DS platform and lowest in the sequential acquisition and split-filter platforms. Advances in knowledge: The results of this study corroborate previous in vivo estimates of iodine detection limits at DECT and provide a comparison for the performance of different DECT platforms at low iodine concentrations in vitro.

Original languageEnglish (US)
Article number20190530
JournalBritish Journal of Radiology
Issue number1104
StatePublished - 2019

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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