Investigations of a CA repeat in the oestrogen receptor β gene in patients with Alzheimer's disease

Charlotte Forsell, Eva Enmark, Karin Axelman, Mari Blomberg, Lars Olof Wahlund, Jan Åke Gustafsson, Lars Lannfelt

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Several studies have shown that oestrogen treatment after menopause decreases the risk for Alzheimer's disease (AD). It is also known that oestrogen stimulates the outgrowth of nerve cells and that apolipoprotein E (Apo E) synthesis and amyloid precursor protein (APP) metabolism are regulated by oestrogen. Recently a new oestrogen receptor was identified, oestrogen receptor β (ERβ), located at chromosome 14q22-24. Several genes close to this chromosomal region have been implicated in AD, but the results are conflicting. Our hypothesis was that variations in the ERβ gene could be the underlying cause to the positive findings in these genes and we have therefore investigated a CA repeat1 in intron 5 of the ERβ gene. Three hundred and thirty-six AD cases and 110 healthy age-matched controls were included in this study. Fourteen different alleles were found with frequencies between 0.1 and 37%. There was no significant difference between AD cases and controls when all alleles were compared. However, allele 5 was seen in 13.6% of the controls but only in 8.0% of AD cases (P=0.014; odds ratio (OR)=0.55). No AD patient homozygous for this allele was seen but three controls were homozygous. In conclusion, our findings suggest the ERβ allele 5 to be a protective factor. However, this has to be confirmed in a larger population.

Original languageEnglish (US)
Pages (from-to)802-804
Number of pages3
JournalEuropean Journal of Human Genetics
Volume9
Issue number10
DOIs
StatePublished - 2001

Keywords

  • Alzheimer's disease
  • Chromosome 14
  • Dementia
  • ERβ
  • Gene
  • Oestrogen receptor β

ASJC Scopus subject areas

  • Genetics(clinical)

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