Investigations into the potential contribution of a thermal mechanism for pulsed high intensity focused ultrasound mediated delivery

Brian O'Neill, King C.P. Li, Victor Frenkel, Howard Vo, Mary Angstadt, Bradford J. Wood, Timothy P. Quinn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery is currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200 nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.

Original languageEnglish (US)
Title of host publication2007 IEEE Ultrasonics Symposium Proceedings, IUS
Pages1-4
Number of pages4
DOIs
StatePublished - Dec 1 2007
Event2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States
Duration: Oct 28 2007Oct 31 2007

Other

Other2007 IEEE Ultrasonics Symposium, IUS
CountryUnited States
CityNew York, NY
Period10/28/0710/31/07

Keywords

  • Drug delivery
  • High intensity focused ultrasound
  • Hyperthermia
  • Thermal mechanism

ASJC Scopus subject areas

  • Engineering(all)

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