Investigations into the potential contribution of a thermal mechanism for pulsed high intensity focused ultrasound mediated delivery

Brian O'Neill; King C.P. Li; Victor Frenkel; Howard Vo; Mary Angstadt; Bradford J. Wood; Timothy P. Quinn

doi:10.1109/ULTSYM.2007.16

Investigations into the potential contribution of a thermal mechanism for pulsed high intensity focused ultrasound mediated delivery

Brian O'Neill, King C.P. Li, Victor Frenkel, Howard Vo, Mary Angstadt, Bradford J. Wood, Timothy P. Quinn

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery is currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200 nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.

Original language	English (US)
Title of host publication	2007 IEEE Ultrasonics Symposium Proceedings, IUS
Pages	1-4
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2007.16
State	Published - Dec 1 2007
Event	2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States Duration: Oct 28 2007 → Oct 31 2007

Other

Other	2007 IEEE Ultrasonics Symposium, IUS
Country/Territory	United States
City	New York, NY
Period	10/28/07 → 10/31/07

Keywords

Drug delivery
High intensity focused ultrasound
Hyperthermia
Thermal mechanism

ASJC Scopus subject areas

Engineering(all)

Access to Document

10.1109/ULTSYM.2007.16

Cite this

O'Neill, B, Li, KCP, Frenkel, V, Vo, H, Angstadt, M, Wood, BJ & Quinn, TP 2007, Investigations into the potential contribution of a thermal mechanism for pulsed high intensity focused ultrasound mediated delivery. in 2007 IEEE Ultrasonics Symposium Proceedings, IUS., 4409589, pp. 1-4, 2007 IEEE Ultrasonics Symposium, IUS, New York, NY, United States, 10/28/07. https://doi.org/10.1109/ULTSYM.2007.16

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title = "Investigations into the potential contribution of a thermal mechanism for pulsed high intensity focused ultrasound mediated delivery",

abstract = "The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery is currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200 nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.",

keywords = "Drug delivery, High intensity focused ultrasound, Hyperthermia, Thermal mechanism",

author = "Brian O'Neill and Li, {King C.P.} and Victor Frenkel and Howard Vo and Mary Angstadt and Wood, {Bradford J.} and Quinn, {Timothy P.}",

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AU - O'Neill, Brian

AU - Li, King C.P.

AU - Frenkel, Victor

AU - Vo, Howard

AU - Angstadt, Mary

AU - Wood, Bradford J.

AU - Quinn, Timothy P.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery is currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200 nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.

AB - The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery is currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200 nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.

KW - Drug delivery

KW - High intensity focused ultrasound

KW - Hyperthermia

KW - Thermal mechanism

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U2 - 10.1109/ULTSYM.2007.16

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M3 - Conference contribution

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BT - 2007 IEEE Ultrasonics Symposium Proceedings, IUS

T2 - 2007 IEEE Ultrasonics Symposium, IUS

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Investigations into the potential contribution of a thermal mechanism for pulsed high intensity focused ultrasound mediated delivery

Abstract

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Keywords

ASJC Scopus subject areas

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