Investigation of a measles outbreak in a fully vaccinated school population including serum studies before and after revaccination

David O. Matson, Carrie L. Byington, Mark Canfield, Paul Albrecht, Ralph D. Feigin

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A measles outbreak in early 1989 among ∼4200 students at a high school and two intermediate schools in suburban Houston, TX, was investigated to evaluate reasons for vaccine failure and to predict the efficacy of a booster dose of measles vaccine. Seventy-seven cases occurred (71 at the high school, 6 at intermediate schools; attack rate, 3.2 and 0.3%, respectively).Vaccination in the first year of life an 13 to 14 years since last vaccination were independent risk factors for being a case. Forty- three (18%) of 239 sera collected from students just before revaccination during the outbreak were negative by enzyme immunoassay; a neutralization assay confirmed these 43 lacked antibody predicting protection against measles infection. Of 43 enzyme immunoassay-negative students 24 gave another blood sample 9 to 10 months after revaccination. Revaccination appeared to reduce the portion of all students with neutralization titers predicting susceptibility to measles illness with rash from 7.9% to 3.0% and left the portion predected to be the susceptibleto illness with out rash unchanged(45%).

Original languageEnglish (US)
Pages (from-to)292-299
Number of pages8
JournalPediatric Infectious Disease Journal
Volume12
Issue number4
DOIs
StatePublished - Jan 1 1993

Keywords

  • Measles
  • antibody
  • protection
  • revaccination

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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