TY - GEN
T1 - Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling
AU - Dogra, Prashant
AU - Butner, Joseph D.
AU - Ramirez, Javier Ruiz
AU - Cristini, Vittorio
AU - Wang, Zhihui
PY - 2020/7
Y1 - 2020/7
N2 - The application of nanomedicine for diagnosis and treatment of cancer has immense potential, but has witnessed only limited clinical success, in part due to insufficient understanding of the role of nanomaterial properties and physiological variables in governing nanoparticle (NP) pharmacology. Here, we present a multiscale mathematical model to examine the effects of physiological changes associated with patient age on the pharmacokinetics and tumor delivery efficiency of NPs. We show that physiological changes due to aging prolong the residence of NPs in the systemic circulation, thereby improving passive accumulation of NPs in tumors.Clinical Relevance - Understanding the effect of inter-individual variability on the pharmacological behavior of nanomaterials will improve their clinical translatability.
AB - The application of nanomedicine for diagnosis and treatment of cancer has immense potential, but has witnessed only limited clinical success, in part due to insufficient understanding of the role of nanomaterial properties and physiological variables in governing nanoparticle (NP) pharmacology. Here, we present a multiscale mathematical model to examine the effects of physiological changes associated with patient age on the pharmacokinetics and tumor delivery efficiency of NPs. We show that physiological changes due to aging prolong the residence of NPs in the systemic circulation, thereby improving passive accumulation of NPs in tumors.Clinical Relevance - Understanding the effect of inter-individual variability on the pharmacological behavior of nanomaterials will improve their clinical translatability.
UR - http://www.scopus.com/inward/record.url?scp=85090996117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090996117&partnerID=8YFLogxK
U2 - 10.1109/EMBC44109.2020.9175322
DO - 10.1109/EMBC44109.2020.9175322
M3 - Conference contribution
C2 - 33018501
AN - SCOPUS:85090996117
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 2447
EP - 2450
BT - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
Y2 - 20 July 2020 through 24 July 2020
ER -