Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling

Prashant Dogra; Joseph D. Butner; Javier Ruiz Ramirez; Vittorio Cristini; Zhihui Wang

doi:10.1109/EMBC44109.2020.9175322

Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling

Prashant Dogra, Joseph D. Butner, Javier Ruiz Ramirez, Vittorio Cristini, Zhihui Wang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

The application of nanomedicine for diagnosis and treatment of cancer has immense potential, but has witnessed only limited clinical success, in part due to insufficient understanding of the role of nanomaterial properties and physiological variables in governing nanoparticle (NP) pharmacology. Here, we present a multiscale mathematical model to examine the effects of physiological changes associated with patient age on the pharmacokinetics and tumor delivery efficiency of NPs. We show that physiological changes due to aging prolong the residence of NPs in the systemic circulation, thereby improving passive accumulation of NPs in tumors.Clinical Relevance - Understanding the effect of inter-individual variability on the pharmacological behavior of nanomaterials will improve their clinical translatability.

Original language	English (US)
Title of host publication	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publication	Enabling Innovative Technologies for Global Healthcare, EMBC 2020
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	2447-2450
Number of pages	4
ISBN (Electronic)	9781728119908
DOIs	https://doi.org/10.1109/EMBC44109.2020.9175322
State	Published - Jul 2020
Event	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, Canada Duration: Jul 20 2020 → Jul 24 2020

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2020-July
ISSN (Print)	1557-170X

Conference

Conference	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
Country	Canada
City	Montreal
Period	7/20/20 → 7/24/20

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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Dogra, P., Butner, J. D., Ramirez, J. R., Cristini, V., & Wang, Z. (2020). Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling. In 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020 (pp. 2447-2450). [9175322] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC44109.2020.9175322

Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling. / Dogra, Prashant; Butner, Joseph D.; Ramirez, Javier Ruiz; Cristini, Vittorio ; Wang, Zhihui.

42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. p. 2447-2450 9175322 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Dogra, P, Butner, JD, Ramirez, JR, Cristini, V & Wang, Z 2020, Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling. in 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020., 9175322, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2020-July, Institute of Electrical and Electronics Engineers Inc., pp. 2447-2450, 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020, Montreal, Canada, 7/20/20. https://doi.org/10.1109/EMBC44109.2020.9175322

Dogra P, Butner JD, Ramirez JR, Cristini V , Wang Z. Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling. In 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc. 2020. p. 2447-2450. 9175322. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC44109.2020.9175322

Dogra, Prashant ; Butner, Joseph D. ; Ramirez, Javier Ruiz ; Cristini, Vittorio ; Wang, Zhihui. / Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling. 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. pp. 2447-2450 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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