Investigating islet immunoisolation parameters using microfabricated membranes

T. A. Desai, D. J. Hansford, W. H. Chu, T. Huen, M. Ferrari

Research output: Contribution to journalConference article

7 Scopus citations

Abstract

The immunoisolation of xenogeneic hormone-secreting cells is a promising therapy for a wide variety of diseases including diabetes, Parkinson's, and hemophilia. By utilizing microfabrication technology, silicon biocapsules can be fabricated with membranes having precisely controlled and uniform pore sizes, allowing one to optimize parameters specifically for the encapsulation of specific hormone-secreting cell types. This study investigates immunoisolation parameters using microfabricated silicon-based membranes, with uniform membrane pore sizes in the tens of nanometer range. The permeability of IgG was studied in microfabricated biocapsules with various pore sized membranes. In addition, immunoisolative characteristics were monitored by assessing viability and functionality of islets within biocapsules.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalMaterials Research Society Symposium - Proceedings
Volume530
DOIs
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 MRS Symposium - San Francisco, CA, USA
Duration: Apr 13 1998Apr 14 1998

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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