Invasive Right Ventricular Pressure-Volume Analysis: Basic Principles, Clinical Applications, and Practical Recommendations

Michael I. Brener, Amirali Masoumi, Vivian G. Ng, Khodr Tello, Marcelo B. Bastos, William K. Cornwell, Steven Hsu, Ryan J. Tedford, Philipp Lurz, Karl Philipp Rommel, Karl Patrik Kresoja, Sherif F. Nagueh, Manreet K. Kanwar, Navin K. Kapur, Gurumurthy Hiremath, Mohammad Sarraf, Antoon J.M. Van Den Enden, Nicolas M. Van Mieghem, Paul M. Heerdt, Rebecca T. HahnSusheel K. Kodali, Gabriel T. Sayer, Nir Uriel, Daniel Burkhoff

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Right ventricular pressure-volume (PV) analysis characterizes ventricular systolic and diastolic properties independent of loading conditions like volume status and afterload. While long-considered the gold-standard method for quantifying myocardial chamber performance, it was traditionally only performed in highly specialized research settings. With recent advances in catheter technology and more sophisticated approaches to analyze PV data, it is now more commonly used in a variety of clinical and research settings. Herein, we review the basic techniques for PV loop measurement, analysis, and interpretation with the aim of providing readers with a deeper understanding of the strengths and limitations of PV analysis. In the second half of the review, we detail key scenarios in which right ventricular PV analysis has influenced our understanding of clinically relevant topics and where the technique can be applied to resolve additional areas of uncertainty. All told, PV analysis has an important role in advancing our understanding of right ventricular physiology and its contribution to cardiovascular function in health and disease.

Original languageEnglish (US)
Pages (from-to)E009101
JournalCirculation: Heart Failure
Issue number1
StatePublished - Jan 1 2022


  • heart failure
  • hemodynamics
  • pulmonary circulation
  • ventricular function, right
  • Ventricular Function, Left/physiology
  • Ventricular Function, Right/physiology
  • Heart Ventricles/physiopathology
  • Humans
  • Stroke Volume/physiology
  • Hemodynamics/physiology
  • Heart Failure/physiopathology
  • Ventricular Dysfunction, Right/physiopathology
  • Ventricular Pressure/physiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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