@article{be29c819f4e84ad19a8998769f8214a3,
title = "Invasive gram-positive bacterial infection in cancer patients",
abstract = "Systematic studies have shown that gram-positive organisms are the leading cause of invasive bacterial disease in patients with cancer. A broad range of gram-positive bacteria cause serious infections in the cancer patient with the greatest burden of disease being due to staphylococci, streptococci, and enterococci. The evolution of cancer therapy and the changing epidemiology of major gram-positive pathogens mean that ongoing efforts are needed to understand and mitigate the impact of these bacteria in patients with malignancy. The development of novel antibacterials, optimization of treatment approaches, implementation of improved vaccines, and manipulation of the microbiome are all active areas of investigation in the goal of improving the survival of the cancer patient through amelioration of the disease burden of gram-positive bacteria.",
keywords = "Antimicrobial resistance, Gram-positive bacteria, Infection, Neutropenia",
author = "Thomas Holland and Fowler, {Vance G.} and Shelburne, {Samuel A.}",
note = "Funding Information: Supplement Sponsorship. This article appeared as part of the supplement “The Third Infections in Cancer Symposium,” sponsored by the National Institute of Health, Agency for Healthcare Research and Quality. Funding Information: Potential conflicts of interest. V. G. F. served as Chair of V710 Scientific Advisory Committee (Merck), has received grant support from Cerexa, Pfizer, Advanced Liquid Logic, MedImmune, has been a paid consultant for Astellas, Affinium, Bayer, Theravance, Cubist, Cerexa, Durata, Merck, Pfizer, NovaDigm, Novartis, Medicines Company, Biosynexus, MedI-mmune, and Inimex, and has received honoraria from Merck, Astellas, Cubist, Pfizer, Theravance, and Novartis. All other authors report no potential conflicts. Funding Information: Financial support. V. G. F. was supported by K24-AI093969 from National Institutes of Health. S. A. S. was supported by R01-AI089891 from National Institutes of Health. The authors apologize to the authors of the many excellent recent studies in this area that could not be cited because of space limitations. Publisher Copyright: {\textcopyright} The Author 2014. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2014",
doi = "10.1093/cid/ciu598",
language = "English (US)",
volume = "59",
pages = "S331--S334",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
}