Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite

Anna Tampieri; Teresa D'Alessandro; Monica Sandri; Simone Sprio; Elena Landi; Luca Bertinetti; Silvia Panseri; Giancarlo Pepponi; Joerg Goettlicher; Manuel Bañobre-López; Jose Rivas

doi:10.1016/j.actbio.2011.09.032

Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite

Anna Tampieri, Teresa D'Alessandro, Monica Sandri, Simone Sprio, Elena Landi, Luca Bertinetti, Silvia Panseri, Giancarlo Pepponi, Joerg Goettlicher, Manuel Bañobre-López, Jose Rivas

Houston Methodist

Research output: Contribution to journal › Article › peer-review

271 Scopus citations

Abstract

The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe ²⁺/Fe ³⁺)-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surgery; in addition, magnetic Fe-HA can find application in anticancer therapies, to replace the widely used magnetic iron oxide nanoparticles, whose long-term cytotoxicity was recently found to reach harmful levels. An extensive physicochemical, microstructural and magnetic characterization was performed on the obtained Fe-HA powders, and demonstrated that the simultaneous addition of Fe ²⁺ and Fe ³⁺ ions during apatite nucleation under controlled synthesis conditions induces intrinsic magnetization in the final product, minimizing the formation of magnetite as secondary phase. This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia.

Original language	English (US)
Pages (from-to)	843-851
Number of pages	9
Journal	Acta Biomaterialia
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/j.actbio.2011.09.032
State	Published - Feb 2012

Keywords

Bone regeneration
Hydroxyapatite
Hyperthermia
Magnetic properties
Superparamagnetism

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Biotechnology
Biochemistry
Molecular Biology

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10.1016/j.actbio.2011.09.032

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title = "Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite",

abstract = "The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe 2+/Fe 3+)-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surgery; in addition, magnetic Fe-HA can find application in anticancer therapies, to replace the widely used magnetic iron oxide nanoparticles, whose long-term cytotoxicity was recently found to reach harmful levels. An extensive physicochemical, microstructural and magnetic characterization was performed on the obtained Fe-HA powders, and demonstrated that the simultaneous addition of Fe 2+ and Fe 3+ ions during apatite nucleation under controlled synthesis conditions induces intrinsic magnetization in the final product, minimizing the formation of magnetite as secondary phase. This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia.",

keywords = "Bone regeneration, Hydroxyapatite, Hyperthermia, Magnetic properties, Superparamagnetism",

author = "Anna Tampieri and Teresa D'Alessandro and Monica Sandri and Simone Sprio and Elena Landi and Luca Bertinetti and Silvia Panseri and Giancarlo Pepponi and Joerg Goettlicher and Manuel Ba{\~n}obre-L{\'o}pez and Jose Rivas",

note = "Funding Information: Gabrielle A. Sblendorio, Duncan T.L. Alexander and Paul Bowen for fruitful discussions. Baptiste Charbonnier and David Marchat for proofreading the manuscript and for providing pertinent suggestions. Bastien Le Gars Santoni thanks the Swiss National Science Foundation for his doctoral scholarship (Grant no. 200021_169027 ). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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AU - Bertinetti, Luca

AU - Panseri, Silvia

AU - Pepponi, Giancarlo

AU - Goettlicher, Joerg

AU - Bañobre-López, Manuel

AU - Rivas, Jose

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N2 - The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe 2+/Fe 3+)-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surgery; in addition, magnetic Fe-HA can find application in anticancer therapies, to replace the widely used magnetic iron oxide nanoparticles, whose long-term cytotoxicity was recently found to reach harmful levels. An extensive physicochemical, microstructural and magnetic characterization was performed on the obtained Fe-HA powders, and demonstrated that the simultaneous addition of Fe 2+ and Fe 3+ ions during apatite nucleation under controlled synthesis conditions induces intrinsic magnetization in the final product, minimizing the formation of magnetite as secondary phase. This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia.

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Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite

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