Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite

Anna Tampieri, Teresa D'Alessandro, Monica Sandri, Simone Sprio, Elena Landi, Luca Bertinetti, Silvia Panseri, Giancarlo Pepponi, Joerg Goettlicher, Manuel Bañobre-López, Jose Rivas

Research output: Contribution to journalArticlepeer-review

219 Scopus citations


The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe 2+/Fe 3+)-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surgery; in addition, magnetic Fe-HA can find application in anticancer therapies, to replace the widely used magnetic iron oxide nanoparticles, whose long-term cytotoxicity was recently found to reach harmful levels. An extensive physicochemical, microstructural and magnetic characterization was performed on the obtained Fe-HA powders, and demonstrated that the simultaneous addition of Fe 2+ and Fe 3+ ions during apatite nucleation under controlled synthesis conditions induces intrinsic magnetization in the final product, minimizing the formation of magnetite as secondary phase. This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia.

Original languageEnglish (US)
Pages (from-to)843-851
Number of pages9
JournalActa Biomaterialia
Issue number2
StatePublished - Feb 2012


  • Bone regeneration
  • Hydroxyapatite
  • Hyperthermia
  • Magnetic properties
  • Superparamagnetism

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology


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