Intraventricular Glioblastomas

Atef Ben Nsir, Yassine Gdoura, Quoc Anh Thai, Alia Zhani Kassar, Nejib Hattab, Hafedh Jemel

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background and Importance Although glioblastoma is the most common primary brain tumor, primary intraventricular locations are extremely rare; only 21 cases have been reported to date. Methods A retrospectively acquired database of all intracranial glioblastomas treated in 2 different neurosurgical departments during the last 10 years was queried. Patients with histologically proven intraventricular glioblastomas were included in the study. Results Eight patients were identified as having a histologically confirmed intraventricular glioblastoma. Patient age at diagnosis ranged from 6 to 74 years (mean 29.6 years) and the male/female ratio was 5:3. Increased intracranial pressure due to hydrocephalus was the main cause of the clinical manifestations. The tumor was located within the lateral ventricle in 6 cases and the anterior third ventricle in 2 others. Gross total tumor excision was achieved in 3 patients, whereas the surgical resection was subtotal in 4 cases and a surgical biopsy was performed in 1 patient. Postoperative adjuvant therapies were administered in 5 patients. Median survival time was 32.1 months, and 3 patients were alive at the end of study. All of them had isocitrate dehydrogenase-mutated tumors. Conclusions Intraventricular glioblastoma is extremely rare and can affect younger individuals including children. This malignant tumor should be included in the differential diagnosis of intraventricular lesions, especially in the lateral ventricles. Radical surgical resection can be associated with remarkable disease-free survival, especially in isocitrate dehydrogenase-mutated tumors. Because recurrence virtually is unavoidable, long-term follow-up is mandatory.

Original languageEnglish (US)
Pages (from-to)126-131
Number of pages6
JournalWorld neurosurgery
StatePublished - Apr 1 2016


  • Glioblastoma
  • Intraventricular tumors
  • Key words Chemotherapy
  • Radiotherapy
  • Transcallosal approach
  • Transcortical approach

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Intraventricular Glioblastomas'. Together they form a unique fingerprint.

Cite this