Intravenous pancuronium bromide was administered into the umbilical cord by funipuncture to effect temporary fetal paralysis. Neuromuscular blockade was achieved in 12 fetuses undergoing a total of 34 intrauterine procedures for the treatment of severe red-cell alloimmunization. The same initial dose of 0.2 mg/kg fetal weight estimated by ultrasound was used in all cases, but anemic fetuses did not resume movement for prolonged periods. A relationship among fetal hematocrit, adjusted dose, and duration of paralysis was described by the equation: Duration (hours) = 5.24 + 10.30 adjusted dose (mg/kg) - 0.16 hematocrit (%) (R2 = 0.49; P <.001). Intravenous pancuronium was found to be a safe and effective method for cessation of fetal movement during intrauterine procedures.
|Original language||English (US)|
|Number of pages||4|
|Journal||Obstetrics and Gynecology|
|State||Published - Jan 1 1989|
ASJC Scopus subject areas
- Obstetrics and Gynecology