Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results

Gooitzen M. Van Dam; George Themelis; Lucia M.A. Crane; Niels J. Harlaar; Rick G. Pleijhuis; Wendy Kelder; Athanasios Sarantopoulos; Johannes S. De Jong; Henriette J.G. Arts; Ate G.J. Van Der Zee; Joost Bart; Philip Low; Vasilis Ntziachristos

doi:10.1038/nm.2472

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results

Gooitzen M. Van Dam, George Themelis, Lucia M.A. Crane, Niels J. Harlaar, Rick G. Pleijhuis, Wendy Kelder, Athanasios Sarantopoulos, Johannes S. De Jong, Henriette J.G. Arts, Ate G.J. Van Der Zee, Joost Bart, Philip Low, Vasilis Ntziachristos

Houston Methodist

Research output: Contribution to journal › Article › peer-review

1452 Scopus citations

Abstract

The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.

Original language	English (US)
Pages (from-to)	1315-1319
Number of pages	5
Journal	Nature Medicine
Volume	17
Issue number	10
DOIs	https://doi.org/10.1038/nm.2472
State	Published - Oct 1 2011

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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Van Dam, G. M., Themelis, G., Crane, L. M. A., Harlaar, N. J., Pleijhuis, R. G., Kelder, W., Sarantopoulos, A., De Jong, J. S., Arts, H. J. G., Van Der Zee, A. G. J., Bart, J., Low, P., & Ntziachristos, V. (2011). Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results. Nature Medicine, 17(10), 1315-1319. https://doi.org/10.1038/nm.2472

Van Dam, GM, Themelis, G, Crane, LMA, Harlaar, NJ, Pleijhuis, RG, Kelder, W, Sarantopoulos, A, De Jong, JS, Arts, HJG, Van Der Zee, AGJ, Bart, J, Low, P & Ntziachristos, V 2011, 'Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results', Nature Medicine, vol. 17, no. 10, pp. 1315-1319. https://doi.org/10.1038/nm.2472

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abstract = "The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95\% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.",

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AU - Arts, Henriette J.G.

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AU - Ntziachristos, Vasilis

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Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results

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