Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results

Gooitzen M. Van Dam, George Themelis, Lucia M.A. Crane, Niels J. Harlaar, Rick G. Pleijhuis, Wendy Kelder, Athanasios Sarantopoulos, Johannes S. De Jong, Henriette J.G. Arts, Ate G.J. Van Der Zee, Joost Bart, Philip Low, Vasilis Ntziachristos

Research output: Contribution to journalArticle

1032 Scopus citations

Abstract

The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.

Original languageEnglish (US)
Pages (from-to)1315-1319
Number of pages5
JournalNature Medicine
Volume17
Issue number10
DOIs
StatePublished - Oct 1 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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