Intradural approach to selective stimulation in the spinal cord for treatment of intractable pain: Design principles and wireless protocol

M. A. Howard; M. Utz; T. J. Brennan; B. D. Dalm; S. Viljoen; N. D. Jeffery; G. T. Gillies

doi:10.1063/1.3626469

Intradural approach to selective stimulation in the spinal cord for treatment of intractable pain: Design principles and wireless protocol

M. A. Howard, M. Utz, T. J. Brennan, B. D. Dalm, S. Viljoen, N. D. Jeffery, G. T. Gillies

Academic Institute

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

We introduce an intradural approach to spinal cord stimulation for the relief of intractable pain, and describe the biophysical rationale that underlies its design and performance requirements. The proposed device relies on wireless, inductive coupling between a pial surface implant and its epidural controller, and we present the results of benchtop experiments that demonstrate the ability to transmit and receive a frequency-modulated 1.6 MHz carrier signal between micro-coil antennae scaled to the ≈ 1 cm dimensions of the implant, at power levels of about 5 mW. Plans for materials selection, microfabrication, and other aspects of future development are presented and discussed.

Original language	English (US)
Article number	044702
Journal	Journal of Applied Physics
Volume	110
Issue number	4
DOIs	https://doi.org/10.1063/1.3626469
State	Published - Aug 15 2011

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.1063/1.3626469

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title = "Intradural approach to selective stimulation in the spinal cord for treatment of intractable pain: Design principles and wireless protocol",

abstract = "We introduce an intradural approach to spinal cord stimulation for the relief of intractable pain, and describe the biophysical rationale that underlies its design and performance requirements. The proposed device relies on wireless, inductive coupling between a pial surface implant and its epidural controller, and we present the results of benchtop experiments that demonstrate the ability to transmit and receive a frequency-modulated 1.6 MHz carrier signal between micro-coil antennae scaled to the ≈ 1 cm dimensions of the implant, at power levels of about 5 mW. Plans for materials selection, microfabrication, and other aspects of future development are presented and discussed.",

author = "Howard, {M. A.} and M. Utz and Brennan, {T. J.} and Dalm, {B. D.} and S. Viljoen and Jeffery, {N. D.} and Gillies, {G. T.}",

note = "Funding Information: We thank our colleagues D. J. O{\textquoteright}Connell (Neuroventures LLC), R. S. Nelson and D. Wessels (Evergreen Medical Technologies LLC), and S. Sheehan (University of Iowa) for several useful technical discussions. This work was funded in part by the University of Iowa GIVF Seed Funds program, the University of Virginia Biomedical Innovation Fund, and the Kopf Family Foundation, Inc. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",

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doi = "10.1063/1.3626469",

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AU - Brennan, T. J.

AU - Dalm, B. D.

AU - Viljoen, S.

AU - Jeffery, N. D.

AU - Gillies, G. T.

N1 - Funding Information: We thank our colleagues D. J. O’Connell (Neuroventures LLC), R. S. Nelson and D. Wessels (Evergreen Medical Technologies LLC), and S. Sheehan (University of Iowa) for several useful technical discussions. This work was funded in part by the University of Iowa GIVF Seed Funds program, the University of Virginia Biomedical Innovation Fund, and the Kopf Family Foundation, Inc. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2011/8/15

Y1 - 2011/8/15

N2 - We introduce an intradural approach to spinal cord stimulation for the relief of intractable pain, and describe the biophysical rationale that underlies its design and performance requirements. The proposed device relies on wireless, inductive coupling between a pial surface implant and its epidural controller, and we present the results of benchtop experiments that demonstrate the ability to transmit and receive a frequency-modulated 1.6 MHz carrier signal between micro-coil antennae scaled to the ≈ 1 cm dimensions of the implant, at power levels of about 5 mW. Plans for materials selection, microfabrication, and other aspects of future development are presented and discussed.

AB - We introduce an intradural approach to spinal cord stimulation for the relief of intractable pain, and describe the biophysical rationale that underlies its design and performance requirements. The proposed device relies on wireless, inductive coupling between a pial surface implant and its epidural controller, and we present the results of benchtop experiments that demonstrate the ability to transmit and receive a frequency-modulated 1.6 MHz carrier signal between micro-coil antennae scaled to the ≈ 1 cm dimensions of the implant, at power levels of about 5 mW. Plans for materials selection, microfabrication, and other aspects of future development are presented and discussed.

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Intradural approach to selective stimulation in the spinal cord for treatment of intractable pain: Design principles and wireless protocol

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