Intraductal Papillary Mucinous Neoplasms of the Pancreas: Current Understanding and Future Directions for Stratification of Malignancy Risk

Annabelle L. Fonseca, Kimberly Kirkwood, Michael P. Kim, Anirban Maitra, Eugene J. Koay

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

The incidence of intraductal papillary mucinous neoplasms (IPMNs) has been increasing over the past decade, mainly owing to increased awareness and the increased use of cross-sectional imaging. The Sendai and Fukuoka consensus guidelines provide us with clinical management guidelines and algorithms; however, the clinical management of IPMNs continues to be challenging. Our incomplete understanding of the natural history of the disease, and the events and pathways that permit progression to adenocarcinoma, result in difficulties predicting which tumors are high risk and will progress to invasive disease. In this review, we summarize the current management guidelines and describe ongoing efforts to more clearly stratify IPMNs by risk of malignancy and identify IPMNs with malignant potential or ongoing malignant transformation.

Original languageEnglish (US)
Pages (from-to)272-279
Number of pages8
JournalPancreas
Volume47
Issue number3
DOIs
StatePublished - Mar 1 2018

Keywords

  • IPMN
  • Management of IPMNs
  • Pancreatic mucinous neoplasms
  • Risk of malignancy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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