Intracranial dual-mode IVUS and hyperthermia using circular arrays: Preliminary experiments

Vivek Patel, Edward Light, Carl Herickhoff, Gerald Grant, Gavin Britz, Christy Wilson, Mark Palmeri, Stephen Smith

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In this study, we investigated the feasibility of using 3.5-Fr (3 Fr = 1 mm) circular phased-array intravascular ultrasound (IVUS) catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: (1) by inserting a 3.5-Fr IVUS catheter through skull burr holes, for 20 MHz brain imaging in the pig model, and (2) by testing a modified circular array for therapy potential with 18.5-MHz and 9-MHz continuous wave (CW) excitation. The imaging transducer's performance was superior to our previous 9-MHz mechanical IVUS prototype. The therapy catheter transducer was driven by CW electrical power at 18.5 MHz, achieving temperature changes reaching +8°C at a depth of 2 mm in a human glioblastoma grown on the flank of a mouse with minimal transducer resistive heating of +2°C. Further hyperthermia trials showed that 9-MHz CW excitation produced temperature changes of +4.5°C at a depth of 12 mm - a sufficient temperature rise for our long-term goal of targeted, controlled drug release via thermosensitive liposomes for therapeutic treatment of 1-cm-diameter glioblastomas.

Original languageEnglish (US)
Pages (from-to)17-29
Number of pages13
JournalUltrasonic Imaging
Volume35
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • dual mode
  • hyperthermia
  • IVUS
  • therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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