Intracranial dual-mode IVUS and hyperthermia using circular arrays

Vivek Patel, Edward Light, Carl Herickhoff, Mark Palmeri, Gerald Grant, Gavin Britz, Christy Wilson, Stephen Smith

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we investigated the feasibility of using 3.5-Fr circular phased array IVUS catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: 1) by fitting a 3.5-Fr IVUS catheter through burr holes, for 20 MHz imaging, and 2) by testing a modified circular array for therapy potential with 18.5-MHz and 9.0 MHz CW excitation. The imaging transducer's performance was compared to our previous 9 MHz mechanical IVUS prototype. The therapy transducer was driven by CW electrical power, achieving temperature changes reaching +8°C at a depth of 2 mm in human glioblastoma tissue grown on the flank of a mouse. Further hyperthermia trials showed that resistive heating of the transducer was minimal producing a +2°C increase with CW excitation.

Original languageEnglish (US)
Title of host publication2011 IEEE International Ultrasonics Symposium, IUS 2011
Pages2185-2188
Number of pages4
DOIs
StatePublished - 2011
Event2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States
Duration: Oct 18 2011Oct 21 2011

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2011 IEEE International Ultrasonics Symposium, IUS 2011
CountryUnited States
CityOrlando, FL
Period10/18/1110/21/11

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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