Interstitial stress and fluid pressure within a growing tumor

Malisa Sarntinoranont, Frank Rooney, Mauro Ferrari

Research output: Contribution to journalArticlepeer-review

127 Scopus citations


Based upon analysis fo the mechanical fields, a framework for modeling regions of vascular collapse within central regions of a solid tumor was developed. The collapse of vessels was a critical issue in the transport of nutrients, waste products, drugs, and other biological agents within the tumor. In addition, vessel collapse was thought to contribute to the development of hypoxic and necrotic regions observed in rapidly growing tumors.

Original languageEnglish (US)
Pages (from-to)327-335
Number of pages9
JournalAnnals of Biomedical Engineering
Issue number3
StatePublished - Jan 1 2003


  • Poroelastic
  • Residual stress
  • Soft tissue mechanics
  • Tumor

ASJC Scopus subject areas

  • Biomedical Engineering


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