Interoperator reliability of an on-site machine learning-based prototype to estimate CT angiography-derived fractional flow reserve

Yushui Han, Ahmed Ibrahim Ahmed, Chris Schwemmer, Myra Cocker, Talal S. Alnabelsi, Jean Michel Saad, Juan C.Ramirez Giraldo, Mouaz H. Al-Mallah

Research output: Contribution to journalArticlepeer-review


Background Advances in CT and machine learning have enabled on-site non-invasive assessment of fractional flow reserve (FFR CT). Purpose To assess the interoperator and intraoperator variability of coronary CT angiography-derived FFR CT using a machine learning-based postprocessing prototype. Materials and methods We included 60 symptomatic patients who underwent coronary CT angiography. FFR CT was calculated by two independent operators after training using a machine learning-based on-site prototype. FFR CT was measured 1 cm distal to the coronary plaque or in the middle of the segments if no coronary lesions were present. Intraclass correlation coefficient (ICC) and Bland-Altman analysis were used to evaluate interoperator variability effect in FFR CT estimates. Sensitivity analysis was done by cardiac risk factors, degree of stenosis and image quality. Results A total of 535 coronary segments in 60 patients were assessed. The overall ICC was 0.986 per patient (95% CI 0.977 to 0.992) and 0.972 per segment (95% CI 0.967 to 0.977). The absolute mean difference in FFR CT estimates was 0.012 per patient (95% CI for limits of agreement: -0.035 to 0.039) and 0.02 per segment (95% CI for limits of agreement: -0.077 to 0.080). Tight limits of agreement were seen on Bland-Altman analysis. Distal segments had greater variability compared with proximal/mid segments (absolute mean difference 0.011 vs 0.025, p<0.001). Results were similar on sensitivity analysis. Conclusion A high degree of interoperator and intraoperator reproducibility can be achieved by on-site machine learning-based FFR CT assessment. Future research is required to evaluate the physiological relevance and prognostic value of FFR CT.

Original languageEnglish (US)
Article numbere001951
JournalOpen Heart
Issue number1
StatePublished - Mar 21 2022


  • Biostatistics
  • Computed Tomography Angiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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