Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway

Xiaojin Sha; Shu Meng; Xinyuan Li; Hang Xi; Massimo Maddaloni; David W. Pascual; Huimin Shan; Xiaohua Jiang; Hong Wang; Xiao Feng Yang

doi:10.1074/jbc.M115.663286

Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway

Xiaojin Sha, Shu Meng, Xinyuan Li, Hang Xi, Massimo Maddaloni, David W. Pascual, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiao Feng Yang

Academic Institute

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Background: Interleukin-35 is a novel inhibitory cytokine. Results: Interleukin-35 inhibits vascular endothelial cell activation by suppressing MAPK-AP1-mediated VACM-1 expression in LPS-induced acute inflammation. Conclusion: Interleukin-35 suppresses acute vascular endothelium response. Significance: Interleukin-35 may be an attractive reagent for anti-inflammatory therapy.

Original language	English (US)
Pages (from-to)	19307-19318
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	290
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M115.663286
State	Published - Jul 31 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M115.663286

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title = "Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway",

abstract = "Background: Interleukin-35 is a novel inhibitory cytokine. Results: Interleukin-35 inhibits vascular endothelial cell activation by suppressing MAPK-AP1-mediated VACM-1 expression in LPS-induced acute inflammation. Conclusion: Interleukin-35 suppresses acute vascular endothelium response. Significance: Interleukin-35 may be an attractive reagent for anti-inflammatory therapy.",

author = "Xiaojin Sha and Shu Meng and Xinyuan Li and Hang Xi and Massimo Maddaloni and Pascual, \{David W.\} and Huimin Shan and Xiaohua Jiang and Hong Wang and Yang, \{Xiao Feng\}",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = jul,

day = "31",

doi = "10.1074/jbc.M115.663286",

language = "English (US)",

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T1 - Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway

AU - Sha, Xiaojin

AU - Meng, Shu

AU - Li, Xinyuan

AU - Xi, Hang

AU - Maddaloni, Massimo

AU - Pascual, David W.

AU - Shan, Huimin

AU - Jiang, Xiaohua

AU - Wang, Hong

AU - Yang, Xiao Feng

PY - 2015/7/31

Y1 - 2015/7/31

N2 - Background: Interleukin-35 is a novel inhibitory cytokine. Results: Interleukin-35 inhibits vascular endothelial cell activation by suppressing MAPK-AP1-mediated VACM-1 expression in LPS-induced acute inflammation. Conclusion: Interleukin-35 suppresses acute vascular endothelium response. Significance: Interleukin-35 may be an attractive reagent for anti-inflammatory therapy.

AB - Background: Interleukin-35 is a novel inhibitory cytokine. Results: Interleukin-35 inhibits vascular endothelial cell activation by suppressing MAPK-AP1-mediated VACM-1 expression in LPS-induced acute inflammation. Conclusion: Interleukin-35 suppresses acute vascular endothelium response. Significance: Interleukin-35 may be an attractive reagent for anti-inflammatory therapy.

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DO - 10.1074/jbc.M115.663286

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AN - SCOPUS:84940480277

SN - 0021-9258

VL - 290

SP - 19307

EP - 19318

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 31

ER -

Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway

Abstract

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