Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway

Xiaojin Sha, Shu Meng, Xinyuan Li, Hang Xi, Massimo Maddaloni, David W. Pascual, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiao Feng Yang

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Background: Interleukin-35 is a novel inhibitory cytokine. Results: Interleukin-35 inhibits vascular endothelial cell activation by suppressing MAPK-AP1-mediated VACM-1 expression in LPS-induced acute inflammation. Conclusion: Interleukin-35 suppresses acute vascular endothelium response. Significance: Interleukin-35 may be an attractive reagent for anti-inflammatory therapy.

Original languageEnglish (US)
Pages (from-to)19307-19318
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number31
DOIs
StatePublished - Jul 31 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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