Interleukin-25 mediated induction of angiogenin-4 is interleukin-13 dependent

Zannatun Noor, Stacey L. Burgess, Koji Watanabe, William A. Petri

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The intestinal surface is directly exposed to both commensal microorganisms as well as pathogens with a single layer of epithelium separating luminal microorganisms from internal tissues. Antimicrobial peptides play a crucial role in allowing epithelial cells to contain in the lumen beneficial and pathogenic microorganisms. The commensal dependent, epithelial produced, Th2 cytokine IL-25 can induce IL-13 and potentially the antimicrobial peptide angiogenin-4. Here we show that IL-13 downstream of IL-25 is required to induce angiogenin-4. IL-25 mediated induction of angiogenin-4 is furthermore not dependent on IL-22 or IL-17.

Original languageEnglish (US)
Article numbere0153572
JournalPLoS ONE
Issue number4
StatePublished - Apr 2016

ASJC Scopus subject areas

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