Interleukin 2 enhances cytotoxic cell function in vitro after T-cell depleted marrow transplantation

O. Leger, H. G. Drexler, J. E. Reittie, L. Secker-Walker, H. Grant Prentice, M. K. Brenner

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

After T-cell depleted marrow transplantation, there is a rapid recovery of cytotoxic effector cells, with activity against targets not susceptible to killing by 'resting' natural killer cells. These targets include Epstein-Barr virus transformed B cells and leukaemic cell lines. Activated killer cell function declines by 3 months after transplantation. We find that when CD3 negative effector cells are obtained from these patients and cultured in vitro with interleukin 2 there is a further enhancement of cytotoxic activity against a range of target cells in the early post-transplant period, and a restoration of high level cytotoxic activity to effector cells obtained 3 months or more after the procedure. These results may have relevance to attempts to reduce the incidence of leukaemic relapse, and EBV + ve lymphoma outgrowth after T-cell depleted BMT.

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalBritish Journal of Haematology
Volume67
Issue number3
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Hematology

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