Interictal Spikes and Hippocampal Somatostatin Levels in Temporal Lobe Epilepsy

Charisse Deutch; Susan Spencer; Richard J. Robbins; Domenic Cicchetti; Dennis Spencer

doi:10.1111/j.1528-1157.1991.tb05241.x

Interictal Spikes and Hippocampal Somatostatin Levels in Temporal Lobe Epilepsy

Charisse Deutch, Susan Spencer, Richard J. Robbins, Domenic Cicchetti, Dennis Spencer

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We investigated the relationship between somatostatin-like immunoreactivity (SSLI) and interictal spikes (IIS) in human temporal lobe epileptic tissue. IIS counted manually from depth electrode recordings obtained preoperatively were expressed as spike frequency in anterior, middle, and posterior portions of hippocampus. SSLI was determined by radioimmunoassay (RIA). An inverse relationship between SSLI in the entorhinal cortex (EC) and IIS frequency in hippocampus was present (r = -0.55, p = 0.06). No correlation between IIS and SSLI in CA4, CA3, CA1, or the dentate was evident. This finding suggests a role of the EC in generation, regulation, or expression of interictal paroxysmal electrical activity in temporal lobe epilepsy (TLE), for which somatostatin may be a marker.

Original language	English (US)
Pages (from-to)	174-178
Number of pages	5
Journal	Epilepsia
Volume	32
Issue number	2
DOIs	https://doi.org/10.1111/j.1528-1157.1991.tb05241.x
State	Published - Jan 1 1991

Keywords

Entorhinal cortex
Epilepsy
Hippocampus
Interictal spikes
Somatostatin

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1111/j.1528-1157.1991.tb05241.x

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abstract = "We investigated the relationship between somatostatin-like immunoreactivity (SSLI) and interictal spikes (IIS) in human temporal lobe epileptic tissue. IIS counted manually from depth electrode recordings obtained preoperatively were expressed as spike frequency in anterior, middle, and posterior portions of hippocampus. SSLI was determined by radioimmunoassay (RIA). An inverse relationship between SSLI in the entorhinal cortex (EC) and IIS frequency in hippocampus was present (r = -0.55, p = 0.06). No correlation between IIS and SSLI in CA4, CA3, CA1, or the dentate was evident. This finding suggests a role of the EC in generation, regulation, or expression of interictal paroxysmal electrical activity in temporal lobe epilepsy (TLE), for which somatostatin may be a marker.",

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AU - Spencer, Dennis

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Interictal Spikes and Hippocampal Somatostatin Levels in Temporal Lobe Epilepsy

Abstract

Keywords

ASJC Scopus subject areas

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