Interferon-Associated Retinopathy

David R. Guyer, James Tiedeman, Lawrence A. Yannuzzi, Jason S. Slakter, David Parke, James Kelley, Rosa A. Tang, Michael Marmor, Gary Abrams, Joan W. Miller, Evangelos S. Gragoudas

Research output: Contribution to journalArticlepeer-review

275 Scopus citations


Interferon alfa is used to treat various systemic disorders and recently has been suggested as a possible treatment for choroidal neovascularization. We report 10 cases of retinal ischemia associated with the use of interferon alfa for various illnesses. The retinal findings include cotton-wool spot formation, capillary nonperfusion, arteriolar occlusion, and hemorrhage. The retinal complications may sometimes be reversible when treatment is stopped. Our findings emphasize the need to have patients who are receiving interferon alfa therapy monitored for these retinal complications, which may rarely be associated with permanent loss of vision secondary to closure of retinal capillaries.

Original languageEnglish (US)
Pages (from-to)350-356
Number of pages7
JournalArchives of Ophthalmology
Issue number3
StatePublished - Mar 1993

ASJC Scopus subject areas

  • Ophthalmology


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