Interferon-Associated Retinopathy

David R. Guyer; James Tiedeman; Lawrence A. Yannuzzi; Jason S. Slakter; David Parke; James Kelley; Rosa A. Tang; Michael Marmor; Gary Abrams; Joan W. Miller; Evangelos S. Gragoudas

doi:10.1001/archopht.1993.01090030068041

Interferon-Associated Retinopathy

David R. Guyer, James Tiedeman, Lawrence A. Yannuzzi, Jason S. Slakter, David Parke, James Kelley, Rosa A. Tang, Michael Marmor, Gary Abrams, Joan W. Miller, Evangelos S. Gragoudas

Research output: Contribution to journal › Article › peer-review

276 Scopus citations

Abstract

Interferon alfa is used to treat various systemic disorders and recently has been suggested as a possible treatment for choroidal neovascularization. We report 10 cases of retinal ischemia associated with the use of interferon alfa for various illnesses. The retinal findings include cotton-wool spot formation, capillary nonperfusion, arteriolar occlusion, and hemorrhage. The retinal complications may sometimes be reversible when treatment is stopped. Our findings emphasize the need to have patients who are receiving interferon alfa therapy monitored for these retinal complications, which may rarely be associated with permanent loss of vision secondary to closure of retinal capillaries.

Original language	English (US)
Pages (from-to)	350-356
Number of pages	7
Journal	Archives of Ophthalmology
Volume	111
Issue number	3
DOIs	https://doi.org/10.1001/archopht.1993.01090030068041
State	Published - Mar 1993

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.1993.01090030068041

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title = "Interferon-Associated Retinopathy",

abstract = "Interferon alfa is used to treat various systemic disorders and recently has been suggested as a possible treatment for choroidal neovascularization. We report 10 cases of retinal ischemia associated with the use of interferon alfa for various illnesses. The retinal findings include cotton-wool spot formation, capillary nonperfusion, arteriolar occlusion, and hemorrhage. The retinal complications may sometimes be reversible when treatment is stopped. Our findings emphasize the need to have patients who are receiving interferon alfa therapy monitored for these retinal complications, which may rarely be associated with permanent loss of vision secondary to closure of retinal capillaries.",

author = "Guyer, {David R.} and James Tiedeman and Yannuzzi, {Lawrence A.} and Slakter, {Jason S.} and David Parke and James Kelley and Tang, {Rosa A.} and Michael Marmor and Gary Abrams and Miller, {Joan W.} and Gragoudas, {Evangelos S.}",

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AU - Guyer, David R.

AU - Tiedeman, James

AU - Yannuzzi, Lawrence A.

AU - Slakter, Jason S.

AU - Parke, David

AU - Kelley, James

AU - Tang, Rosa A.

AU - Marmor, Michael

AU - Abrams, Gary

AU - Miller, Joan W.

AU - Gragoudas, Evangelos S.

PY - 1993/3

Y1 - 1993/3

N2 - Interferon alfa is used to treat various systemic disorders and recently has been suggested as a possible treatment for choroidal neovascularization. We report 10 cases of retinal ischemia associated with the use of interferon alfa for various illnesses. The retinal findings include cotton-wool spot formation, capillary nonperfusion, arteriolar occlusion, and hemorrhage. The retinal complications may sometimes be reversible when treatment is stopped. Our findings emphasize the need to have patients who are receiving interferon alfa therapy monitored for these retinal complications, which may rarely be associated with permanent loss of vision secondary to closure of retinal capillaries.

AB - Interferon alfa is used to treat various systemic disorders and recently has been suggested as a possible treatment for choroidal neovascularization. We report 10 cases of retinal ischemia associated with the use of interferon alfa for various illnesses. The retinal findings include cotton-wool spot formation, capillary nonperfusion, arteriolar occlusion, and hemorrhage. The retinal complications may sometimes be reversible when treatment is stopped. Our findings emphasize the need to have patients who are receiving interferon alfa therapy monitored for these retinal complications, which may rarely be associated with permanent loss of vision secondary to closure of retinal capillaries.

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Interferon-Associated Retinopathy

Abstract

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