Interferon-α in high-risk melanoma patients

Janice N. Cormier, Yan Xing, Merrick I. Ross, Scott B. Cantor

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The incidence of melanoma has been climbing steadily since the early 1970s. Although melanoma can be successfully cured by surgical excision in its early stages, it is the most common fatal form of skin cancer. The most critical factors in determining the prognosis for patients with melanoma are primary tumor thickness, ulceration and the status of regional lymph nodes. Surgical treatment alone is inadequate in patients with thick, ulcerated tumors and those with nodal disease, as shown by poor 5-year disease-specific survival rates. Despite the fact that high-dose interferon-α has been approved for the treatment of high-risk melanoma by the US Food and Drug Administration and regulatory agencies worldwide, current treatment recommendations vary widely due to the conflicting trial data and significant toxicity and cost associated with high-dose interferon-α.

Original languageEnglish (US)
Pages (from-to)667-676
Number of pages10
JournalExpert Review of Pharmacoeconomics and Outcomes Research
Volume4
Issue number6
DOIs
StatePublished - Dec 2004

Keywords

  • Cost effectiveness
  • Interferon-α
  • Melanoma

ASJC Scopus subject areas

  • Health Policy
  • Pharmacology (medical)

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