Interest of [18F]fluorodeoxyglucose positron emission tomography/computed tomography for the diagnosis of relapse in patients with spinal infection: A prospective study

F. A. Dauchy, A. Dutertre, S. Lawson-Ayayi, H. de Clermont-Gallerande, C. Fournier, P. Zanotti-Fregonara, H. Dutronc, J. M. Vital, M. Dupon, P. Fernandez

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Relapse after treatment of a spinal infection is infrequent and difficult to diagnose. The aim of this study was to assess the diagnostic performance of [18F]fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in this setting. Thirty patients (21 men, nine women; median age 61.2 years) with a suspected spinal infection relapse were prospectively included between March 2010 and June 2013. The initial diagnosis of spinal infection was confirmed by positive bacterial cultures. The patients underwent [18F]FDG PET/CT and magnetic resonance imaging (MRI) 1 month after antibiotic treatment interruption. PET/CT data were interpreted both visually and semi-quantitatively (SUVmax). The patients were followed for ≥12 months and the final diagnosis of relapse was based on new microbiological cultures. Seven patients relapsed during follow up. Sensitivity, specificity, positive predictive value and negative predictive value were 66.6%, 61.9%, 33.3% and 86.6%, respectively for MRI and 85.7, 82.6, 60.0 and 95.0 for PET/CT. Although these values were higher for PET/CT than for MRI, the difference was not statistically significant (p=0.3). [18F]FDG PET/CT may be useful for diagnosing a relapse of spinal infections, in particular if metallic implants limit the performance of MRI.

Original languageEnglish (US)
Pages (from-to)438-443
Number of pages6
JournalClinical Microbiology and Infection
Volume22
Issue number5
DOIs
StatePublished - May 1 2016

Keywords

  • Diagnosis
  • Implant
  • PET/CT
  • Relapse
  • Spinal infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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