Intercellular junctions in 'shock lung'. A freeze fracture study

R. Barrios, S. Inoue, J. C. Hogg

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Intercellular junctions in the alveolar epithelium and in the capillary endothelium in lung from 5 dogs after hemorrhagic shock (mean blood pressure, 40 mm. Hg for 3 hr) and from 5 control dogs were observed in the electron microscope using the freeze-fracture technique. Following shock zonulae occludentes (tight junctions) in the alveolar epithelium showed alterations in substructure that were not present in control animals. These changes were morphologically similar to those reported in junctions altered after exposure to osmotic gradients with marked degradation and disappearance of junctional strands. The appearance of tight junctions in the capillary endothelium, which were of a rather poorly organized 'leaky' type in control animals, was generally unaltered after shock. Disintegration and disappearance of junctional strands in 'focal' regions, however, were occasionally observed. The increased pulmonary capillary permeability observed physiologically after hemorrhagic shock could be explained by such alterations of endothelial zonulae occludentes.

Original languageEnglish (US)
Pages (from-to)628-635
Number of pages8
JournalLaboratory Investigation
Issue number6
StatePublished - 1977

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology


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