Interactions of ibuprofen with hybrid lipid bilayers probed by complementary surface-enhanced vibrational spectroscopies

Carly S Levin, Janardan Kundu, Benjamin G Janesko, Gustavo E Scuseria, Robert M. Raphael, Naomi J. Halas

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

The incorporation of small molecules into lipid bilayers is a process of biological importance and clinical relevance that can change the material properties of cell membranes and cause deleterious side effects for certain drugs. Here we report the direct observation, using surface-enhanced Raman and IR spectroscopies (SERS, SEIRA), of the insertion of ibuprofen molecules into hybrid lipid bilayers. The alkanethiol-phospholipid hybrid bilayers were formed onto gold nanoshells by self-assembly, where the underlying nanoshell substrates provided the necessary enhancements for SERS and SEIRA. The spectroscopic data reveal specific interactions between ibuprofen and phospholipid moieties and indicate that the overall hydrophobicity of ibuprofen plays an important role in its intercalation in these membrane mimics.

Original languageEnglish (US)
Pages (from-to)14168-75
Number of pages8
JournalJournal of Physical Chemistry B
Volume112
Issue number45
DOIs
StatePublished - Nov 13 2008

Keywords

  • Adsorption
  • Anti-Inflammatory Agents, Non-Steroidal
  • Ibuprofen
  • Lipid Bilayers
  • Nanostructures
  • Spectrophotometry, Infrared
  • Spectrum Analysis, Raman
  • Surface Properties
  • Vibration
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

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