Interaction of peroxynitrite with mitochondrial cytochrome oxidase. Catalytic production of nitric oxide and irreversible inhibition of enzyme activity

Chemistry

• Inhibition of Enzyme 100%
• Peroxynitrite 90%
• Nitric Oxide 68%
• Cytochrome 63%
• Enzyme Activity 59%
• Irreversible Enzyme Inhibition 15%
• Heme 14%
• Proteoliposome 10%
• Redox State 9%
• Dioxygen 7%
• Reduction 7%
• Electron Transfer 5%
• Lipid 5%
• Red 5%
• Metal 3%

Medicine & Life Sciences

• Peroxynitrous Acid 91%
• Electron Transport Complex IV 85%
• Nitric Oxide 58%
• Enzymes 39%
• Cytochromes a 35%
• Cytochromes a3 20%
• heme a 17%
• proteoliposomes 15%
• Oxygen 14%
• Cyanides 13%
• Lipid Bilayers 12%
• Cytochromes 11%
• Heme 11%
• Oxidation-Reduction 9%
• Catalytic Domain 9%
• Metals 8%
• Electrons 8%