Interaction of 6-methyl-1,3,8-trichlorodibenzofuran with tcdd-induced vitamin A reduction

F. Wærn, A. Hanberg, E. Manzoor, S. Safe, U. G. Ahlborg

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) have been shown to inhibit TCDD-induced enzymeinduction both in rat and in cell culture. MCDF, alone or together with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), was administered to rats in order to investigate the ability of MCDF to reduce TCDD-induced vitamin A depletion. High doses of MCDF induced vitamin A-depletion, but no inhibitory effect on TCDD-induced depletion was seen in this experiment.

Original languageEnglish (US)
Pages (from-to)1005-1008
Number of pages4
JournalChemosphere
Volume19
Issue number1-6
DOIs
StatePublished - 1989

Keywords

  • 2,3,7,8-tetrachlorodibenzo-p-dioxin
  • 6-methyl-1,3,8-trichlorodibenzofuran
  • 7-ethoxyresorufin O-deethylase
  • EROD
  • TCDD
  • vitamin A

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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