Interaction of 6-methyl-1,3,8-trichlorodibenzofuran with tcdd-induced vitamin A reduction

F. Wærn; A. Hanberg; E. Manzoor; S. Safe; U. G. Ahlborg

doi:10.1016/0045-6535(89)90449-9

Interaction of 6-methyl-1,3,8-trichlorodibenzofuran with tcdd-induced vitamin A reduction

F. Wærn, A. Hanberg, E. Manzoor, S. Safe, U. G. Ahlborg

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) have been shown to inhibit TCDD-induced enzymeinduction both in rat and in cell culture. MCDF, alone or together with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), was administered to rats in order to investigate the ability of MCDF to reduce TCDD-induced vitamin A depletion. High doses of MCDF induced vitamin A-depletion, but no inhibitory effect on TCDD-induced depletion was seen in this experiment.

Original language	English (US)
Pages (from-to)	1005-1008
Number of pages	4
Journal	Chemosphere
Volume	19
Issue number	1-6
DOIs	https://doi.org/10.1016/0045-6535(89)90449-9
State	Published - 1989

Keywords

2,3,7,8-tetrachlorodibenzo-p-dioxin
6-methyl-1,3,8-trichlorodibenzofuran
7-ethoxyresorufin O-deethylase
EROD
TCDD
vitamin A

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
Chemistry(all)
Pollution
Health, Toxicology and Mutagenesis

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10.1016/0045-6535(89)90449-9

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title = "Interaction of 6-methyl-1,3,8-trichlorodibenzofuran with tcdd-induced vitamin A reduction",

abstract = "6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) have been shown to inhibit TCDD-induced enzymeinduction both in rat and in cell culture. MCDF, alone or together with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), was administered to rats in order to investigate the ability of MCDF to reduce TCDD-induced vitamin A depletion. High doses of MCDF induced vitamin A-depletion, but no inhibitory effect on TCDD-induced depletion was seen in this experiment.",

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T1 - Interaction of 6-methyl-1,3,8-trichlorodibenzofuran with tcdd-induced vitamin A reduction

AU - Wærn, F.

AU - Hanberg, A.

AU - Manzoor, E.

AU - Safe, S.

AU - Ahlborg, U. G.

PY - 1989

Y1 - 1989

N2 - 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) have been shown to inhibit TCDD-induced enzymeinduction both in rat and in cell culture. MCDF, alone or together with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), was administered to rats in order to investigate the ability of MCDF to reduce TCDD-induced vitamin A depletion. High doses of MCDF induced vitamin A-depletion, but no inhibitory effect on TCDD-induced depletion was seen in this experiment.

AB - 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) have been shown to inhibit TCDD-induced enzymeinduction both in rat and in cell culture. MCDF, alone or together with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), was administered to rats in order to investigate the ability of MCDF to reduce TCDD-induced vitamin A depletion. High doses of MCDF induced vitamin A-depletion, but no inhibitory effect on TCDD-induced depletion was seen in this experiment.

KW - 2,3,7,8-tetrachlorodibenzo-p-dioxin

KW - 6-methyl-1,3,8-trichlorodibenzofuran

KW - 7-ethoxyresorufin O-deethylase

KW - EROD

KW - TCDD

KW - vitamin A

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Interaction of 6-methyl-1,3,8-trichlorodibenzofuran with tcdd-induced vitamin A reduction

Abstract

Keywords

ASJC Scopus subject areas

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