Intensity modulated radiotherapy (IMRT) decreases treatment-related morbidity and potentially enhances tumor control

Bin S. Teh, Wei Yuan Mai, Walter H. Grant, J. Kam Chiu, Hsin H. Lu, L. Steven Carpenter, Shiao Y. Woo, E. Brian Butler

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Intensity modulated radiation therapy (IMRT), a new form of three-dimensional conformal radiation therapy (3DCRT), optimizes the concept of computer-controlled radiation deposition in tumor (target) while sparing adjacent normal structures. A retrospective review was done on the initial 185 patients with tumors in different sites including prostate cancer, head and neck cancer, pediatric tumors, adult brain tumors, and previously irradiated recurrent tumors treated with IMRT. Preliminary findings indicate that IMRT is a new clinically feasible tool in radiation oncology. Treatment-related morbidity profile was favorable. Tumor response, local control, and the ability to palliate previously irradiated patients are encouraging. Intensity modulated radiation therapy will allow dose escalation, leading to better tumor control.

Original languageEnglish (US)
Pages (from-to)437-451
Number of pages15
JournalCancer Investigation
Volume20
Issue number4
DOIs
StatePublished - 2002

Keywords

  • Brain tumors
  • Head and neck cancer
  • Intensity modulated radiation therapy
  • Prostate cancer
  • Recurrent cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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