Intelligent testing strategy and analytical techniques for the safety assessment of nanomaterials

Rui Chen, Jiyan Qiao, Ru Bai, Yuliang Zhao, Chunying Chen

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


Nanomaterials (NMs) are widely used in various areas because of their unique and useful physicochemical properties. However, they may pose toxicity risks to human health after exposure. Applicable and reliable approaches are needed for risk assessment of NMs. Herein, an intelligent analytical strategy for safety assessment of NMs is proposed that focuses on toxicity assessment using an in vitro cell model. The toxicity assessment by testing on the adverse outcome pathway in a cell culture system was defined by application of a tiered testing approach. To provide an overview of the applicable approach for risk assessment of NMs, we discuss the most commonly used techniques and analytical methods, including computational toxicology methods in dosimetry assessment, high-throughput screening for toxicity testing with high efficiency, and omics-based toxicology assessment methods. The final section focuses on the route map for an integrated approach to a testing and assessment strategy on how to extrapolate the in vitro NM toxicity testing data to in vivo risk assessment of NMs. The intelligent analytical strategy, having evolved step-by-step, could contribute to better applications for safety evaluation and risk assessment of NMs in reality.

Original languageEnglish (US)
Pages (from-to)6051-6066
Number of pages16
JournalAnalytical and Bioanalytical Chemistry
Issue number24
StatePublished - Sep 1 2018


  • Adverse outcome pathway
  • Computational nanotoxicology
  • Dosimetry
  • Nanoparticles
  • Nanotoxicology
  • Risk assessment
  • Cell Transformation, Neoplastic/chemically induced
  • Nanostructures/chemistry
  • Risk Assessment
  • Humans
  • Toxicity Tests/methods
  • Computational Biology/methods
  • Signal Transduction/drug effects
  • Animals

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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