Integrin-targeted nanoparticles for siRNA delivery

Noa Ben-Arie, Ranit Kedmi, Dan Peer

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Abstract

Integrins are heterodimeric membrane glycoproteins composed of noncovalently associated α and β subunits. Integrins support cell attachment and migration on the surrounding extracellular matrix as well as mediate cell-cell interaction in physiological and pathological settings. Constant recycling of integrins from the plasma membrane to the endosome makes integrins ideal receptors for the delivery of drugs to the cell cytoplasm. RNA interference (RNAi) has evolved not only as a powerful tool for studying gene expression and validating new drug targets, but also as a potential therapeutic intervention. However, the major challenge facing the translation of RNAi into clinical practice is the lack of efficient systemic delivery to specific cell types. Utilizing integrins as delivery target, we have recently devised a strategy to target leukocytes termed Integrin-targeted and stabilized NanoParticles (I-tsNPs) that entrap high RNAi payloads and deliver them in a leukocyte-specific manner to induce robust gene silencing.

Original languageEnglish (US)
Title of host publicationIntegrin and Cell Adhesion Molecules
Subtitle of host publicationMethods and Protocols
EditorsMotomu Shimaoka, Motomu Shimaoka
Pages497-507
Number of pages11
DOIs
StatePublished - Oct 24 2011

Publication series

NameMethods in Molecular Biology
Volume757
ISSN (Print)1064-3745

Keywords

  • Gene silencing
  • Hyaluronan
  • Leukocyte integrins
  • Nanomedicine
  • Nanoparticles
  • siRNAs

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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