Integration of systemic and liver-directed therapies for locally advanced hepatocellular cancer: Harnessing potential synergy for new therapeutic horizons

Eric H. Bent, Eric Wehrenberg-Klee, Eugene J. Koay, Lipika Goyal, Jennifer Y. Wo

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Treatment options in locally advanced hepatocellular carcinoma (HCC) have evolved considerably over the past few years with the recent approval of multiple systemic therapies and significant advances in locoregional therapy. Given the poor prognosis for patients with unresectable HCC, there is significant interest in rationally designed combination therapies. This article reviews the treatment options available to patients with locally advanced HCC and discusses the rationale, ongoing trials, and future prospects for combining locoregional and systemic therapy in both the definitive and neoadjuvant settings.

Original languageEnglish (US)
Pages (from-to)567-576
Number of pages10
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume19
Issue number5
DOIs
StatePublished - May 2021

ASJC Scopus subject areas

  • Oncology

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