Abstract
A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release. (Figure Presented).
Original language | English (US) |
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Pages (from-to) | 7615-7621 |
Number of pages | 7 |
Journal | Advanced Materials |
Volume | 26 |
Issue number | 45 |
DOIs | |
State | Published - Dec 3 2014 |
Keywords
- Biomedical applications
- Dendrimers
- Drug delivery
- Lipids
- Nanomedicine
- Self-assembly
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering