Integration of nanoassembly functions for an effective delivery cascade for cancer drugs

Qihang Sun; Xuanrong Sun; Xinpeng Ma; Zhuxian Zhou; Erlei Jin; Bo Zhang; Youqing Shen; Edward A. Van Kirk; William J. Murdoch; Joseph R. Lott; Timothy P. Lodge; Maciej Radosz; Yuliang Zhao

doi:10.1002/adma.201401554

Integration of nanoassembly functions for an effective delivery cascade for cancer drugs

Qihang Sun, Xuanrong Sun, Xinpeng Ma, Zhuxian Zhou, Erlei Jin, Bo Zhang, Youqing Shen, Edward A. Van Kirk, William J. Murdoch, Joseph R. Lott, Timothy P. Lodge, Maciej Radosz, Yuliang Zhao

Houston Methodist

Research output: Contribution to journal › Article › peer-review

345 Scopus citations

Abstract

A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release. (Figure Presented).

Original language	English (US)
Pages (from-to)	7615-7621
Number of pages	7
Journal	Advanced Materials
Volume	26
Issue number	45
DOIs	https://doi.org/10.1002/adma.201401554
State	Published - Dec 3 2014

Keywords

Biomedical applications
Dendrimers
Drug delivery
Lipids
Nanomedicine
Self-assembly

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201401554

Cite this

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title = "Integration of nanoassembly functions for an effective delivery cascade for cancer drugs",

abstract = "A {"}cluster-bomb{"}-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like {"}bomblets{"}, enabling tumor penetration, cell internalization, and drug release. (Figure Presented).",

keywords = "Biomedical applications, Dendrimers, Drug delivery, Lipids, Nanomedicine, Self-assembly",

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TY - JOUR

T1 - Integration of nanoassembly functions for an effective delivery cascade for cancer drugs

AU - Sun, Qihang

AU - Sun, Xuanrong

AU - Ma, Xinpeng

AU - Zhou, Zhuxian

AU - Jin, Erlei

AU - Zhang, Bo

AU - Shen, Youqing

AU - Van Kirk, Edward A.

AU - Murdoch, William J.

AU - Lott, Joseph R.

AU - Lodge, Timothy P.

AU - Radosz, Maciej

AU - Zhao, Yuliang

PY - 2014/12/3

Y1 - 2014/12/3

N2 - A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release. (Figure Presented).

AB - A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release. (Figure Presented).

KW - Biomedical applications

KW - Dendrimers

KW - Drug delivery

KW - Lipids

KW - Nanomedicine

KW - Self-assembly

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Integration of nanoassembly functions for an effective delivery cascade for cancer drugs

Abstract

Keywords

ASJC Scopus subject areas

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