Integration of Molecular Signaling into Multiscale Modeling of Cancer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Multiscale modeling has now been well-accepted as a powerful tool to quantitatively represent, simulate, understand, and predict cancer progression and development across multiple biological scales. In this chapter, we focus on a specific type of multiscale cancer models where molecular signaling profiles are explicitly linked to the determination of cellular phenotypic changes. These models are particularly suitable for exploring the relationship between signaling dynamics within each individual cancer cell and the emergent cancer behavior on the multicellular level. We also discuss current challenges and future directions of this molecular signaling-incorporated multiscale cancer modeling approach.

Original languageEnglish (US)
Title of host publicationStudies in Mechanobiology, Tissue Engineering and Biomaterials
PublisherSpringer
Pages381-394
Number of pages14
DOIs
StatePublished - 2013

Publication series

NameStudies in Mechanobiology, Tissue Engineering and Biomaterials
Volume14
ISSN (Print)1868-2006
ISSN (Electronic)1868-2014

Keywords

  • Agent-based modeling
  • E-cadherin
  • Epidermal growth factor receptor
  • Hybrid modeling
  • Multiscale

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanics of Materials
  • Biomaterials
  • Biotechnology
  • Biophysics
  • Medicine (miscellaneous)

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