Integrated prototype for point-of-care diagnosis of chlamydia trachomatis infections

Shivani Sathish, Kazumi Toda-Peters, Amy Q. Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Clinical research has shown that bacterial Chlamydia trachomatis infections are the most prevalent sexually transmitted infections, contributing to high rates of miscarriages and infertility worldwide. These infections are conventionally diagnosed via laboratory-based serological tests that quantify C.trachomatis-specific antibodies from patient blood. [1] These expensive and time-consuming tests are being replaced by “at home” testing kits that allow the patients to obtain the diagnosis without repetitive clinical visits. However, these kits heavily rely on the precision of the user to perform the procedures, leading to increased variability in diagnostic results. Here, we developed an integrated palm-sized antibody-testing prototype consisting of a Fluid Handling Device (FHD), that allows precise sample mixing, filtration and delivery of the processed fluids to an on-board microfluidic assay device for detection of C.trachomatis-specific antibodies, within an enclosed, manually-operated system, while decreasing contamination and enabling rapid and replicable antibody detection.

Original languageEnglish (US)
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages1580-1581
Number of pages2
ISBN (Electronic)9781733419000
StatePublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: Oct 27 2019Oct 31 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period10/27/1910/31/19

Keywords

  • At-home tests
  • Fluid handling device
  • Microfluidic immunoassay
  • Sexually transmitted infections

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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