Integrated III-V semiconductor flow cytometer with capillary fill micro-fluidics

R. Thomas, M. Holton, A. Sobiesierski, S. Gillgrass, H. D. Summers, D. Barrow, P. M. Smowton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The potential of the device is demonstrated through the results of a micro-bead counting experiment. A 0.5 μl sample volume containing 10 μm polystyrene micro-beads in Dl water is deposited into an on-chip inlet reservoir from where it flows, under capillary action, through a buried flow cell. A laser on one side of the cell is forward biased and the opposing laser is operated as a photodiode (Fig. 2(a)). Both are pulsed to provide sub-μs time-resolution of bead transit 'events' with a 30 mV noise floor that affords a large dynamic range of over 1.2 V (Fig. 2(b)). After passing through the flow cell the sample fluid is drawn into a spiral patterned exit reservoir that provides sufficient pull through to sustain a continuous flow for over 30 s with flow rate of > 4mm/s.

Original languageEnglish (US)
Title of host publication2015 IEEE Photonics Conference, IPC 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages7-8
Number of pages2
ISBN (Electronic)9781479974658
DOIs
StatePublished - Nov 9 2015
EventIEEE Photonics Conference, IPC 2015 - Reston, United States
Duration: Aug 30 2015Aug 31 2015

Publication series

Name2015 IEEE Photonics Conference, IPC 2015

Other

OtherIEEE Photonics Conference, IPC 2015
CountryUnited States
CityReston
Period8/30/158/31/15

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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