Integrated expression of glomerular extracellular matrix proteins and β1 integrins in monoclonal light chain-related renal diseases

Elba A. Turbat-Herrera, Jorge Isaac, Paul W. Sanders, Luan Truong, Guillermo A. Herrera

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Light-chain deposition disease (LCDD) and amyloid light-chain amyloidosis (AL-Am) represent the two classical diseases associated with glomerular alterations in monoclonal light chain-related renal diseases. LCDD is characterized by deposition of extracellular matrix proteins in the mesangium, thus creating the morphologic appearance recognized as nodular glomerulosclerosis. In AL-Am, the mesangial matrix is replaced by polymerized light chains in the form of amyloid fibrils. Integrins are responsible for cell-to-cell and cell-to-matrix communication and, therefore, are expected to play a key role in the alterations encountered in these two diseases. The present article addresses the expression of selected extracellular matrix proteins (collagen IV, laminin, fibronectin, and tenascin) and their respective receptor β1 integrins (α2, α3, α5, and α9) in glomeruli with LCDD and AL-Am by immunohistochemical methods. The corresponding integrin (α9β1) co-localized with tenascin in the center of the mesangial nodules in LCDD. In AL-Am, tenascin is found primarily at the periphery of replaced mesangial areas and in the remaining mesangium not replaced by the amyloid. Tenascin co-localizes with α9β1 integrin in mesangial areas in the earlier phases of the process. Fibronectin, laminin, and collagen IV, although increased in absolute amounts, are pushed toward the periphery of mesangial areas, in which correlated expression of their corresponding β1 integrins (α2, α3, and α5, respectively) is documented in both LCDD and AL-Am. Deposition of tenascin might be at least partially responsible for the perpetuation and irreversibility of the glomerular lesion in LCDD.

Original languageEnglish (US)
Pages (from-to)485-495
Number of pages11
JournalModern Pathology
Issue number5
StatePublished - May 1997


  • Amyloidosis
  • Extracellular matrix
  • Integrins
  • Kidney
  • Light Chain Deposition Disease
  • Myeloma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Integrated expression of glomerular extracellular matrix proteins and β1 integrins in monoclonal light chain-related renal diseases'. Together they form a unique fingerprint.

Cite this