Intact fetal cells in maternal plasma: Are they really there?

Farideh Z. Bischoff, Sinuhe Hahn, Kirby L. Johnson, Joe Leigh Simpson, Diana W. Bianchi, Dorothy E. Lewis, William D. Weber, Katherine Klinger, Sherman Elias, Laird G. Jackson, Mark I. Evans, Wolfgang Holzgreve, Felix De la Cruz

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Rare fetal cells can be recovered from maternal blood, which suggests that non-invasive prenatal diagnosis is possible. However, recovery and analysis of fetal cells from blood is complex, and sensitivity is low because of the rarity of these cells in the maternal circulation. An alternative strategy, which suggested that intact fetal cells can be found in maternal plasma by use of simple enrichment methods, has been reported. We aimed to replicate this technique. However, five independent laboratories were unable to identify any intact male cells from the plasma of 38 women known to be carrying male fetuses. Although apoptotic intact fetal cells could contribute to the detection of fetal DNA in maternal plasma, we believe that recovery of these cells is difficult and not clinically practical.

Original languageEnglish (US)
Pages (from-to)139-140
Number of pages2
JournalLancet
Volume361
Issue number9352
DOIs
StatePublished - Jan 11 2003

ASJC Scopus subject areas

  • Medicine(all)

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